MOTS-c

Description

MOTS-c Overview

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene rather than in nuclear DNA. That places it among the small group of mitochondrial-derived peptides, and makes it a subject of research into signaling between the mitochondria and the rest of the cell.

MOTS-c was described in 2015, following work that searched the mitochondrial genome for short open reading frames able to encode functional peptides. It extended a line of research that began with humanin, the first mitochondrial-derived peptide to be characterized. Preclinical work since has examined the peptide in models of metabolic regulation and cellular stress response.

MOTS-c Research Focus

Published laboratory and preclinical work on this peptide has concentrated on the following areas:

• Mitochondria-to-cell signaling
• Metabolic regulation in preclinical models
• Cellular stress response
• Mitochondrial genome as a source of regulatory peptides

MOTS-c Identifiers

Available Formats

MOTS-c is available in 10mg vials. Each strength can be ordered as a single vial or as a pack of 10 vials; choose your options above before adding to the cart.

Handling and Storage

Store and handle this product according to the product label and your laboratory’s standard operating procedures. For background on the factors that affect stability, such as temperature, moisture, light and repeated freeze-thaw cycles, read our guide to peptide storage and stability.

Where MOTS-c Fits in Our Range

These compounds are studied for their roles in mitochondrial function, bioenergetics and redox balance. SS-31 is a Szeto-Schiller peptide designed to concentrate in the inner mitochondrial membrane, MOTS-c is a peptide encoded in the mitochondrial genome, NAD+ is a central redox coenzyme and L-Glutathione is the main intracellular antioxidant tripeptide.

Choosing a Format

The strength printed on a vial describes the total amount of material it contains, not a concentration. Work out how much material each planned experiment uses before ordering. The 10-vial pack suits a longer series of experiments, while a single vial suits a pilot run.

General Laboratory Handling

These are general principles for handling lyophilized peptides. The label and your own procedures take priority over them.

• Lyophilized peptides are generally far more stable than peptides in solution, so keep material dry until it is needed.
• Store sealed vials cold and away from light and moisture.
• Let a cold vial reach room temperature before opening it, so that condensation does not form on the powder.
• Divide reconstituted material into single-use aliquots to avoid repeated freeze-thaw cycles.
• Record the lot number, the date opened and the diluent used.

Checking Identity and Purity

Identity, purity and peptide content are separate questions. Mass spectrometry is typically used to confirm molecular mass, reversed-phase HPLC to assess purity, and amino acid analysis to measure peptide content. Our overview of analytical techniques in peptide research explains how these methods work and what each result can and cannot show.

Further Reading

Search PubMed for published MOTS-c research.

MOTS-c FAQs

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene rather than in nuclear DNA.

What has this peptide been studied for?

Published work has concentrated on Mitochondria-to-cell signaling and metabolic regulation in preclinical models. See the research focus section above for the full list.

Which strengths are available?

10mg, each sold as a single vial or as a pack of 10 vials.

Can this product be used in people or animals?

No. It is sold only for laboratory research, and we cannot give dosing or human-use guidance.

Where can I ask a question about this product?

Use our contact page, or email support@directpeptiides.com. Include your order number if your question is about an order.

Related Research Peptides

• SS-31: SS-31 is a synthetic aromatic-cationic tetrapeptide from the Szeto-Schiller series, designed to concentrate in the inner mitochondrial membrane.
• NAD+: NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme central to redox reactions and bioenergetic processes.
• L-Glutathione: L-Glutathione is a ubiquitous tripeptide that acts as a primary intracellular antioxidant and redox regulator.

Browse the full Mitochondrial & Cellular Research range or search the shop.