MOTS-c

Description

MOTS-c Overview

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene rather than in nuclear DNA. That places it among the small group of mitochondrial-derived peptides, and makes it a subject of research into signaling between the mitochondria and the rest of the cell.

MOTS-c was described in 2015, following work that searched the mitochondrial genome for short open reading frames able to encode functional peptides. It extended a line of research that began with humanin, the first mitochondrial-derived peptide to be characterized. Preclinical work since has examined the peptide in models of metabolic regulation and cellular stress response.

MOTS-c Research Focus

Published laboratory and preclinical work on MOTS-c has concentrated on the following areas:

• Mitochondria-to-cell signaling
• Metabolic regulation in preclinical models
• Cellular stress response
• Mitochondrial genome as a source of regulatory peptides

MOTS-c Identifiers

Available Formats

MOTS-c is available in 10mg vials. Each strength can be ordered as a single vial or as a pack of 10 vials; choose your options above before adding to the cart.

Handling and Storage

Store and handle MOTS-c according to the product label and your laboratory’s standard operating procedures. For background on the factors that affect stability, such as temperature, moisture, light and repeated freeze-thaw cycles, read our guide to peptide storage and stability.

Related Research Peptides

• SS-31
• NAD+
• L-Glutathione

Browse the full Mitochondrial & Cellular Research range or search the shop.