Kisspeptin

Description

Kisspeptin Overview

Kisspeptin is a central signaling molecule in the hypothalamic-pituitary-gonadal (HPG) axis and a key modulator of neuroendocrine signaling. The name covers a family of peptides ranging from kisspeptin-10 to kisspeptin-54, all of which bind the receptor KISS1R.

Through KISS1R activation on target neurons, kisspeptin influences pulsatile signaling, the initiation of developmental pathways and endocrine regulation. Research models examine its role in neuroendocrine signaling cascades, feedback loop dynamics and developmental biology.

Kisspeptin Research Focus

Published laboratory and preclinical work on this peptide has concentrated on the following areas:

• HPG axis signaling
• KISS1R activation
• Pulsatile signaling dynamics
• Feedback loop dynamics

Available Formats

Kisspeptin is available in 10mg vials. Each strength can be ordered as a single vial or as a pack of 10 vials; choose your options above before adding to the cart.

Handling and Storage

Store and handle this product according to the product label and your laboratory’s standard operating procedures. For background on the factors that affect stability, such as temperature, moisture, light and repeated freeze-thaw cycles, read our guide to peptide storage and stability.

Where Kisspeptin Fits in Our Range

This category covers peptides studied in neuronal, neuroendocrine and behavioral signaling research. It includes the heptapeptides Selank and Semax, DSIP, Oxytocin, the HPG axis regulator Kisspeptin and VIP (vasoactive intestinal peptide).

Choosing a Format

The strength printed on a vial describes the total amount of material it contains, not a concentration. Work out how much material each planned experiment uses before ordering. The 10-vial pack suits a longer series of experiments, while a single vial suits a pilot run.

General Laboratory Handling

These are general principles for handling lyophilized peptides. The label and your own procedures take priority over them.

• Lyophilized peptides are generally far more stable than peptides in solution, so keep material dry until it is needed.
• Store sealed vials cold and away from light and moisture.
• Let a cold vial reach room temperature before opening it, so that condensation does not form on the powder.
• Divide reconstituted material into single-use aliquots to avoid repeated freeze-thaw cycles.
• Record the lot number, the date opened and the diluent used.

Checking Identity and Purity

Identity, purity and peptide content are separate questions. Mass spectrometry is typically used to confirm molecular mass, reversed-phase HPLC to assess purity, and amino acid analysis to measure peptide content. Our overview of analytical techniques in peptide research explains how these methods work and what each result can and cannot show.

Reference

Jayasena et al. (2014); Trevisan et al. (2018). Find this reference on PubMed.

Kisspeptin FAQs

What is Kisspeptin?

Kisspeptin is a central signaling molecule in the hypothalamic-pituitary-gonadal (HPG) axis and a key modulator of neuroendocrine signaling.

What has this peptide been studied for?

Published work has concentrated on HPG axis signaling and kISS1R activation. See the research focus section above for the full list.

Which strengths are available?

10mg, each sold as a single vial or as a pack of 10 vials.

Can this product be used in people or animals?

No. It is sold only for laboratory research, and we cannot give dosing or human-use guidance.

Where can I ask a question about this product?

Use our contact page, or email support@directpeptiides.com. Include your order number if your question is about an order.

Related Research Peptides

• Oxytocin: Oxytocin is a cyclic nonapeptide with a disulfide bridge between cysteines at positions 1 and 6.
• DSIP: DSIP is a small nine-amino-acid amphiphilic peptide studied for circadian and neuroendocrine signaling.
• PT-141: PT-141, also known as Bremelanotide, is a synthetic peptide analog of α-MSH.

Browse the full Neuropeptides & Neuroendocrine range or search the shop.