IGF-1 LR3

Description

IGF-1 LR3 Overview

IGF-1 LR3 is an 83-amino-acid synthetic polypeptide engineered to get around limitations of native IGF-1. It carries two modifications: an arginine in place of glutamic acid at position 3, and a 13-residue N-terminal extension (MFPAMPLSSLFVN).

These changes reduce binding to IGF binding proteins (IGFBPs) by around 100-fold while keeping full receptor activation, which gives it greater bioavailability and a longer half-life than native IGF-1. Research models examine tyrosine kinase signaling, the PI3K-Akt and Ras-MAPK pathways, substrate uptake, protein synthesis and cell proliferation.

IGF-1 LR3 Research Focus

Published laboratory and preclinical work on this peptide has concentrated on the following areas:

• Tyrosine kinase receptor signaling
• PI3K-Akt and Ras-MAPK pathways
• Protein synthesis in experimental models
• Effect of reduced IGFBP binding

Available Formats

IGF-1 LR3 is available in 1mg vials. Each strength can be ordered as a single vial or as a pack of 10 vials; choose your options above before adding to the cart.

Handling and Storage

Store and handle this product according to the product label and your laboratory’s standard operating procedures. For background on the factors that affect stability, such as temperature, moisture, light and repeated freeze-thaw cycles, read our guide to peptide storage and stability.

Where IGF-1 LR3 Fits in Our Range

This category brings together peptides studied for their effects on the somatotroph (growth hormone) axis. It includes GHRH analogs such as Sermorelin, Tesamorelin, CJC-1295 No DAC and CJC-1295 with DAC, secretagogue-type peptides such as Ipamorelin and Hexarelin, and the IGF-1 analog IGF-1 LR3.

Choosing a Format

The strength printed on a vial describes the total amount of material it contains, not a concentration. Work out how much material each planned experiment uses before ordering. The 10-vial pack suits a longer series of experiments, while a single vial suits a pilot run.

General Laboratory Handling

These are general principles for handling lyophilized peptides. The label and your own procedures take priority over them.

• Lyophilized peptides are generally far more stable than peptides in solution, so keep material dry until it is needed.
• Store sealed vials cold and away from light and moisture.
• Let a cold vial reach room temperature before opening it, so that condensation does not form on the powder.
• Divide reconstituted material into single-use aliquots to avoid repeated freeze-thaw cycles.
• Record the lot number, the date opened and the diluent used.

Checking Identity and Purity

Identity, purity and peptide content are separate questions. Mass spectrometry is typically used to confirm molecular mass, reversed-phase HPLC to assess purity, and amino acid analysis to measure peptide content. Our overview of analytical techniques in peptide research explains how these methods work and what each result can and cannot show.

Reference

Francis et al. (1992); Castellino et al. (1992). Find this reference on PubMed.

IGF-1 LR3 FAQs

What is IGF-1 LR3?

IGF-1 LR3 is an 83-amino-acid synthetic polypeptide engineered to get around limitations of native IGF-1.

What has this peptide been studied for?

Published work has concentrated on Tyrosine kinase receptor signaling and pI3K-Akt and Ras-MAPK pathways. See the research focus section above for the full list.

Which strengths are available?

1mg, each sold as a single vial or as a pack of 10 vials.

Can this product be used in people or animals?

No. It is sold only for laboratory research, and we cannot give dosing or human-use guidance.

Where can I ask a question about this product?

Use our contact page, or email support@directpeptiides.com. Include your order number if your question is about an order.

Related Research Peptides

• CJC-1295 with DAC: CJC-1295 with DAC is a synthetic 30-amino-acid GHRH analog conjugated to a Drug Affinity Complex (DAC) that binds serum albumin.
• CJC-1295 No DAC: CJC-1295 No DAC is a modified GHRH(1-29) analog with four amino acid substitutions that resist DPP-4 degradation.
• Hexarelin: Hexarelin is a synthetic hexapeptide secretagogue with enhanced stability compared with natural ligands.

Browse the full Growth Hormone Axis Peptides range or search the shop.