IGF-1 LR3

Description

IGF-1 LR3 Overview

IGF-1 LR3 is an 83-amino-acid synthetic polypeptide engineered to get around limitations of native IGF-1. It carries two modifications: an arginine in place of glutamic acid at position 3, and a 13-residue N-terminal extension (MFPAMPLSSLFVN).

These changes reduce binding to IGF binding proteins (IGFBPs) by around 100-fold while keeping full receptor activation, which gives it greater bioavailability and a longer half-life than native IGF-1. Research models examine tyrosine kinase signaling, the PI3K-Akt and Ras-MAPK pathways, substrate uptake, protein synthesis and cell proliferation.

IGF-1 LR3 Research Focus

Published laboratory and preclinical work on IGF-1 LR3 has concentrated on the following areas:

• Tyrosine kinase receptor signaling
• PI3K-Akt and Ras-MAPK pathways
• Protein synthesis in experimental models
• Effect of reduced IGFBP binding

Available Formats

IGF-1 LR3 is available in 1mg vials. Each strength can be ordered as a single vial or as a pack of 10 vials; choose your options above before adding to the cart.

Handling and Storage

Store and handle IGF-1 LR3 according to the product label and your laboratory’s standard operating procedures. For background on the factors that affect stability, such as temperature, moisture, light and repeated freeze-thaw cycles, read our guide to peptide storage and stability.

Reference

Francis et al. (1992); Castellino et al. (1992). Find this reference on PubMed.

Related Research Peptides

• CJC-1295 with DAC
• CJC-1295 No DAC
• Hexarelin

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